Why is there a day and night product?

Ideally you want a constant presence of butyrate in the gut during the entire 24 hour day cycle. Because our intestines are more active in the morning and daytime and least active at night, there are two products requiring different ingredients to address the different digestion processes.

The day version is a fast-acting formula, which responds more quickly to your active digestive system. The daytime formulation contains Sodium Butyrate and Calcium D-Glucarate. The sodium salts typically stimulate adrenal function and keep adrenals active during the day. Calcium D-Glucarate prevents intestinal reabsorption of various toxins and metabolites, which is more active during the day.

The night version is a slow-acting formula that works steadily over a longer period of time when our digestion is not very active. The nighttime formulation contains calcium/magnesium butyrate and L-Glutamine. L-Glutamine is a vital restorer of the intestinal lining and is a main precursor of the gamma-aminobutyric acid (GABA) the key inhibitory neurotransmitter and one of the key regulators of circadian rhythm. GABA function includes regulation of the neuronal network covering the entire digestive tract. Therefore, the evening/night glutamine-associate elevation of GABA normalizes the nocturnal ‘misbehavior’ of the gut frequently observed in people with leaky gut syndrome. The urinary excretion/wasting of calcium and magnesium is at a max during the night. Therefore, by using calcium and magnesium butyrate in the evening we are reconstituting the ‘scheduled’ loss of these macroelements.

What is the end goal?

The goal of this protocol is to send your leaky gut into remission.

When can I expect relief?

You can expect to find relief in 3-4 months. And healed in 6 months (typically).

Say I am in remission and I eat something on the banned list. How little does it take for leaky gut to come back? Will it come back if I cheat a little? Or is it a continuous build up?

Yes it can come back. The severity depends on an individual's food intolerance threshold. In general, even consuming a small amount of a ‘forbidden’ food that is above your threshold can easily disturb the balance for several weeks.

Are these products safe for children?

We do not recommend the Leaky Gut Aid products that have butyrate in them (Leaky Gut Day and Night) for children under 16 years of age. Butyrate significantly affects metabolism of cells (osteoblasts) responsible for bone growth. In teenagers this can result in the delayed closure of the bone growth zones and excessive bone length. Conversely, in adults this butyrate property may benefit osteoporotic bones. In addition, in children, butyrate stimulates production of fetal hemoglobin and therefore can influence the bone marrow production of red blood cells. In contrast to healthy kids, this can benefit children with sickle cell anemia. The Leaky Gut Probiotic is safe for children who are at least 80 pounds.

How is leaky gut diagnosed?

Leaky gut is a functional disorder that impairs the normal function of a bodily process, but the body looks completely normal under examination. It's like having a headache, you can't see it, but you know you have it. There are two lab tests that measure the degree of permeability. One is a xylose test and the other is a zonulin test. A D-xylose test determines how well the intestines absorb a simple sugar (D-xylose). The test helps determine if nutrients are being properly absorbed. Zonulin is a protein that upon binding to its receptor, causes the disassembly of tight gap junctions and increased permeability within the intestines.

Where can a person get the xylose and zonulin test?

These tests are performed in specialized gastrointestinal labs with a health practitioners referral.

I had an endoscopy and colonoscopy. Would Leaky Gut have been apparent during those procedures? My GI never mentioned it.

You cannot see Leaky Gut on an endoscopy or colonoscopy as it is a functional disorder-- the body looks completely normal under examination. It's like having a headache, you can't see it, but you know you have it.

Do you recommend taking colostrum to heal faster?

Not really because colostrum has traces of casein which can irritate the gut. And people who are gluten intolerant often times are intolerant to casein as well.

What is butyrate?

Butyrate is a short chain fatty acid derived from the microbial fermentation of dietary fibers in the colon. Butyrate salts, including calcium and magnesium butyrate, are the regulators of intestinal integrity and gene expression (both in the intestine and in various internal organs). At the intestinal level, butyrate regulates fluid transport, controls intestinal permeability, modulates inflammatory and immune responses, suppresses yeast (candida) overgrowth and optimizes intestinal motility.

Additional literature on butyrate (very technical language).

Sodium Butyrate Inhibits Pathogenic Yeast Growth and Enhances the Functions of Macrophages (PDF)
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice (PDF)
Inhibition of Histone Deacetylase Activity by Butyrate (PDF)
The Epigenetic Effects of Butyrate: Potential Therapeutic Implications for Clinical Practice (PDF)
Leaky Gut Syndrome: How Does it Relate to Gluten Intolerance (easy reading)

Our products are certified gluten free by the Celiac Sprue Association